Adverse drug interactions are responsible for over 125,000 deaths annually in the United States alone and contribute to roughly 1.3 million emergency department visits each year. The average elderly patient takes five or more medications, creating dozens of potential interaction pairs that pharmacists must check manually. A single missed interaction between a common blood thinner and an antibiotic can cause fatal bleeding. AI drug interaction checkers are transforming medication safety. These systems cross-reference thousands of known interactions in milliseconds, but more importantly, they can identify emerging interactions from adverse event databases before they appear in standard references. One hospital system reported a 35% reduction in adverse drug events after implementing an AI-powered interaction screening tool at the point of prescribing.